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2011 Fiscal Year Final Research Report

Intra/extracellular nanoprobe arrays for electrical and chemical nanoscale measurements of neurons

Research Project

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Project/Area Number 22760251
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Electron device/Electronic equipment
Research InstitutionToyohashi University of Technology

Principal Investigator

KAWANO Takeshi  豊橋技術科学大学, 大学院・工学研究科, 准教授 (70452216)

Research Collaborator NUMANO Rika  豊橋技術科学大学, エレクトロニクス先端融合研究所, 特任准教授 (30462716)
Project Period (FY) 2010 – 2011
Keywordsナノプローブ / 細胞内電極 / 細胞内プローブ / ドラッグデリバリーシステム / 集積回路 / MEMS / vapor-liquid-solid 成長法 / 脳・神経科学
Research Abstract

We developed out-of-plane, high aspect ratio, nanoscale electrode tipped microwire arrays for applications to penetrating, multisite, nanoscale biological sensors. A nanoscale tipped wire is formed with isotropic silicon etching to the tip of a vapor-liquid-solid grown silicon microwire. After coating the wire with a metal, only the nanotip section can be exposed from the surrounding outer shell(e. g., silicon dioxide and parylene) by three-dimensional integration processes. As a device application, we demonstrate the trapping of polystyrene nanoparticles in a solution using a fabricated gold-nanotip wire array. Moreover, these trapped nanoparticles can be injected into a soft material(gelatin), demonstrating a multi-site wide-area batch depth injection of nanoparticles. Also, we demonstrated multipoint/batch and localized DNA transfers into individual human embryonic kidney cells(HEK293) with plasmid containing yellow fluorescent protein(YFP) gene. Deep area electrical nanoscale measurements for thick samples such as brain slices as well as cortices would also be possible by using the nanotip microwire arrays, promising a powerful device for the future of neuroscience.

  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (6 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Heterogeneously Integrated Vapor-liquid-solid Grown Silicon Probes/(111) and Silicon MOSFETs/(100)2011

    • Author(s)
      Akihiro Okugawa, Kotaro Mayumi, Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Journal Title

      IEEE Electron Device Letters

      Volume: Vol.32 No.5 Pages: 683-685

  • [Journal Article] Out-of-plane High-density Piezoresistive Silicon Microwire/p-n Diode Array for Force-and Temperature-Sensitive Artificial Whisker Sensors2011

    • Author(s)
      Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Journal Title

      Journal of Micromechanics and Microengineering

      Volume: Vol.21, No.3 Pages: 035007

  • [Journal Article] Enlarged Gold-tipped Silicon Microprobe Arrays and Signal Compensation for Multi-site Electroretinogram Recordings in the Isolated Carp Retina2011

    • Author(s)
      Tetsuhiro Harimoto, Kuniharu Takei, Takeshi Kawano, Akito Ishihara, Takahiro Kawashima, Hidekazu Kaneko, Makoto Ishida and Shiro Usui
    • Journal Title

      Biosensors and Bioelectronics

      Volume: Vol.26, No.5 Pages: 2368-2375

  • [Journal Article] Nanoscale Sharpening Tips of Vapor-liquid-solid Grown Silicon Microwire Arrays2010

    • Author(s)
      Akihiro Goryu, Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Journal Title

      Nanotechnology

      Volume: Vol.21, No.12 Pages: 125302

  • [Journal Article] Electrical Interfacing between Neurons and Electronics via Vertically integrated Sub-4 Micron-diameter Silicon Probe Arrays Fabricated by Vapor Vapor-liquid-solid Growth2010

    • Author(s)
      Takeshi Kawano, Tetsuhiro Harimoto, Akito Ishihara, Kuniharu Takei, Takahiro Kawashima, Shiro Usui and Makoto Ishida
    • Journal Title

      Biosensors and Bioelectronics

      Volume: Vol.25, No.7 Pages: 1809-1815

  • [Journal Article] Microtube-based Electrode Arrays for Low Invasive Extracellular Recording with a High Signal-to-noise Ratio2010

    • Author(s)
      Kuniharu Takei, Takeshi Kawano, Takahiro Kawashima, Kazuaki Sawada, Hidekazu Kaneko and Makoto Ishida
    • Journal Title

      Biomedical Microdevices

      Volume: Vol.12, No.1 Pages: 41-48

  • [Presentation] Nanoprobe Array for Gene Transfer into Individual Cells2012

    • Author(s)
      Akihiro Goryu, Rika Numano, Makoto Ishida and Takeshi Kawano
    • Organizer
      2012 MRS Spring Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20120400
  • [Presentation] Hybrid Penetrating-and Planer-Microelectrode Array for Simultaneous Recording of ECoG and Intracortical Neural Activity2012

    • Author(s)
      Tatsuya Imashioya, Akifumi Fujishiro, Hirohito Sawahata, Haruo Toda, Akihito Ikedo, Makoto Ishida, Isao Hasegawa and Takeshi Kawano
    • Organizer
      2012 MRS Spring Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20120400
  • [Presentation] Layer-by-layer Nanoassembly of Iridium Oxide/Platinum-black for Low Impedance, High Charge Injecting Microelectrode Applications2012

    • Author(s)
      Shota Yamagiwa, Akifumi Fujishiro, Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Organizer
      IEEE Micro Electro Mechanical Systems(IEEE-MEMS) Conference 2012
    • Place of Presentation
      Paris, France
    • Year and Date
      20120100
  • [Presentation] Fabrication of Force Sensitive Penetrating Electrical Neuroprobe Arrays2012

    • Author(s)
      Shogo Morita, Akifumi Fujishiro, Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Organizer
      IEEE Micro Electro Mechanical Systems(IEEE-MEMS) Conference 2012
    • Place of Presentation
      Paris, France
    • Year and Date
      20120100
  • [Presentation] Electrical Catching and Transfer of Nanoparticles via Nanotip Silicon Probe Arrays2011

    • Author(s)
      Akihiro Goryu, Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Organizer
      16th International Conference on Solid-State Sensors, Actuators and Microsystems(Transducers' 11)
    • Place of Presentation
      Beijing, China
    • Year and Date
      20110600
  • [Presentation] Temperature Sensitive Microwire Arrays for Artificial Whisker Electronics2011

    • Author(s)
      Akihito Ikedo, Makoto Ishida and Takeshi Kawano
    • Organizer
      IEEE Micro Electro Mechanical Systems(IEEE-MEMS) Conference 2011
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      20110100
  • [Presentation] A Penetrating Micro-scale Diameter Probe Array for in-vivo Neuron Spike Recordings2011

    • Author(s)
      Akifumi Fujishiro, Hidekazu Kaneko, Takahiro Kawashima, Makoto Ishida and Takeshi Kawano
    • Organizer
      IEEE Micro Electro Mechanical Systems(IEEE-MEMS) Conference 2011
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      20110100
  • [Presentation] A Vertical Micro-scale Light Guiding Silicon Dioxide Tube Array for Optical Neurostimulator2011

    • Author(s)
      Masahiro Sakata, Akihiro Goryu, Akihito Ikedo, Tetsuhiro Harimoto, Makoto Ishida and Takeshi Kawano
    • Organizer
      IEEE Micro Electro Mechanical Systems(IEEE-MEMS) Conference 2011
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      20110100
  • [Remarks]

    • URL

      http://www.int.ee.tut.ac.jp/icg/member/~takekawano

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Published: 2013-07-31  

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