2012 Fiscal Year Final Research Report
Study on a novel meiosis specific chromosomal factor in vertebrate
| Project/Area Number |
22770001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 減数分裂 / 染色体 / 生殖細胞 / コヒーシン |
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| Research Abstract |
We identified a novel cohesin subunit RAD21L which isspecifically expressed in meiotic prophase. The meiosis-specific cohesins REC8 and RAD21Lhave been shown to localize along axial elements in a mutually exclusive manner until pachytene inmammalian meiosis. We examined the processes of axial element (AE) formation by comparablyanalyzing Rec8KO, Rad21LKO and Rec8/Rad21L double KO. Disruption of both REC8 andRAD21L abolishes AE formation, suggesting that meiotic cohesins are essential for AE formation.
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