2011 Fiscal Year Final Research Report
Physiological significance of phosphatidylinositol 3-kinase complexes
| Project/Area Number |
22770031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Saitama University |
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Principal Investigator |
FUJIKI Yuki 埼玉大学, 大学院・理工学研究科, 助教 (00414011)
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| Project Period (FY) |
2010 – 2011
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| Keywords | オートファジー / 液胞 / 膜輸送 / リン脂質 / シグナリング |
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| Research Abstract |
ATG6/VPS30, which is a component of yeast phosphatidylinositol 3-kinase(PI3-kinase)complexes, is involved in autophagy and vacuolar protein sorting(VPS)pathway. In higher eukaryotes, however, significance of ATG6/VPS30 homologues in vesicle trafficking has been in dispute. In this study, I created atatg6 homozygous Arabidopsis plants, which exhibited severe growth defects. PI3 kinase activity seems to be severely reduced in this mutant. Microarray analyses revealed that numerous genes are induced in atatg6 mutant. This mutant should serve as a model system for further investigating novel physiological functions of plant PI3K complexes.
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