2012 Fiscal Year Final Research Report
The mechanism for length regulation of thick filament by muscle elastic protein connectin
| Project/Area Number |
22770065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Chiba University |
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Principal Investigator |
HANASHIMA Akira 千葉大学, 大学院・理学研究科, 特任研究員 (70572981)
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| Project Period (FY) |
2010 – 2012
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| Keywords | コネクチン / 横紋筋 |
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| Research Abstract |
We found a novel protein that binds to muscle elastic protein connectin. Our analysis indicates this protein locates at the edge of myosin filament and neuron-muscular junction on striated muscles, and the gene of this protein includes twenty-five exons and produces five splicing isoforms. Additionally, we identified the binding proteins and a break-down protein of novel protein, and also found the existence of this protein in various animals including human and Drosophila.
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[Journal Article] Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways
Author(s)
Rudolf R, Bogomolovas J, Strack S, Choi K, Khan MM, Wagner A, Brohm K, Hanashima A, Gasch A, Labeit D, Labeit S
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DOI
Peer Reviewed
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