2012 Fiscal Year Final Research Report
Investigation of the interaction mechanism for multiple presequences by mitochondrial Tom20
| Project/Area Number |
22770104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Hokkaido University (2012)
Kyushu University (2010-2011) |
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Principal Investigator |
SAITOH Takashi 北海道大学, 大学院・薬学研究院, 技術職員 (00432914)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子認識及び相互作用 |
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| Research Abstract |
In previous study, we proposed that a dynamic equilibrium betweenthe multiple bound states is the molecular mechanism of the broadly selective specificity ofthe Tom20 receptor towards the divergent mitochondrial presequences. In this study, wecarried out X-ray crystal structure analysis and NMR spectroscopy experiments using newcomplexes between Tom20 and presequenses. We attempted to express of full lengthTom20 protein.
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Research Products
(4 results)
