2011 Fiscal Year Final Research Report
Analysis of new function of Hair keratin in epidermis and hair follicle morphogenesis
| Project/Area Number |
22770119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
NANASHIMA Naoki 弘前大学, 大学院・保健学研究科, 講師 (80333730)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞骨格 |
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| Research Abstract |
We used hair keratin-deficient rats (Hirosaki hairless rats, HHRs) that have abnormal hair follicle morphogenesis to determine the function of hair keratin in the epidermis and hair follicle morphogenesis. In transcriptome analysis, expression of the keratin-associated protein (KRTAP) gene critically decreased in HHRs. Thus, we believe that hair keratin functions as a regulator of KRTAP gene expression and decreases expression of genes that cause abnormal hair follicle morphogenesis.
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