2011 Fiscal Year Final Research Report
Mechanism of large protein secretion coordinated by the small GTPase and the ER-resident proteins
| Project/Area Number |
22770120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAITO Kota 東京大学, 大学院・薬学系研究科, 助教 (60549632)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分泌 / コラーゲン / 小胞体 / COPII / 癌 |
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| Research Abstract |
Collagen synthesized in the ER is too big to fit into conventional transport carriers and the mechanism how collagens export from the ER is still largely unclear. Here we show that cTAGE5 localizes to the ER exit sites and forms a complex with TANGO1, a previously characterized cargo receptor for collagen VII. cTAGE5 as well as TANGO1 is required for collagen VII secretion. We propose that cTAGE5 acts as a co-receptor of TANGO1 for collagen VII export from the ER.
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