2012 Fiscal Year Final Research Report
Biochemical screen and functional analysis of a protein complexrequired for selective degradation of mitochondria
| Project/Area Number |
22770124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OKAMOTO Noriko 大阪大学, 生命機能研究科, 特任研究員 (90568750)
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| Research Collaborator |
OKAMOTO Koji 大阪大学, 生命機能研究科, 特任准教授 (40455217)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ミトコンドリア / 出芽酵母 / 膜ダイナミクス / 品質管理 / オートファジー |
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| Research Abstract |
Selective degradation of damaged or surplus mitochondria is important for cellular homeostasis. Recently, it has been proposed that degradation of mitochondria, termed mitophagy, is critical for mitochondrial quality control system. However, the molecular mechanisms remain largely unkown. We identified the specific mitochondrial receptor Atg32 that is essential for the mitophagy using budding yeast. In this study, we performed the biochemical screening and identified novel factors interacting with Atg32.
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Research Products
(7 results)
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[Journal Article] Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy2012
Author(s)
Kondo-Okamoto, N., Noda, N.N., Suzuki,S.W., Nakatogawa, H., Takahashi, I., Matsunami, M., Hashimoto, A., Inagaki,F., Ohsumi, Y., Okamoto, K.
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Journal Title
J. Biol. Chem
Volume: 287: 10631-10638
DOI
Peer Reviewed
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