2011 Fiscal Year Final Research Report
Identification of novel kinases in Wnt signaling
| Project/Area Number |
22770127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Akira 大阪大学, 大学院・医学系研究科, 助教 (70464302)
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| Project Period (FY) |
2010 – 2011
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| Keywords | Wntシグナル / リン酸化酵素 / Dvl / LRP5/ 6 |
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| Research Abstract |
Wnts control various cellular functions including proliferation, differentiation, death, migration, and polarity, by activating multiple intracellular signaling cascades including the.β-catenin-dependent and-independent pathways. Dishevelled(Dvl), which has multiple phosphorylation sites, is an essential intracellular component for both pathways. However, the detailed mechanisms and regulations of Wnt signaling cascades through Dvl have still been poorly understood. In this study, I performed siRNA library screenings to identify novel kinases that phosphorylate Dvl.
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