2011 Fiscal Year Final Research Report
Molecular mechanisms of mRNA decay that is triggered by translation arrest.
| Project/Area Number |
22770129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
HOSODA Nao 名古屋市立大学, 大学院・薬学研究科, 講師 (40438198)
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| Project Period (FY) |
2010 – 2011
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| Keywords | mRNA分解 / 翻訳制御 / G蛋白質 / リボソーム |
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| Research Abstract |
In this study, we examined quality control mechanisms for mRNA lacking in-frame termination codons(non-stop mRNA) using mammalian cells. The non-stop mRNA is unstable and degraded in a translation-dependent manner. The decay requires another eRF3-eRF1 family member Hbs1-Dom34.Also, the elimination of aberrant proteins produced from the non-stop transcripts requires Listerin, which functions as an E3 ubiquitin ligase.
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