2011 Fiscal Year Final Research Report
Molecular recognition mechanism of the small serum proteins(SSPs) events at venomous snake serum against venomous proteins.
| Project/Area Number |
22770134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
SHIOI Narumi (AOKI Narumi) 福岡大学, 理学部, 助教 (50510187)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 蛇毒蛋白質 / 毒蛇血清蛋白質 / 生体防御機構 / アポトーシス誘導蛋白質 |
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| Research Abstract |
Snake venom contains many proteins with several pharmacological functions. On the other hand, endogenous inhibitors of these venomous proteins are present in the snake serum. However, the molecular mechanisms of recognition and inactivation of these inhibitors are unknown. This study has clarified how they specifically inhibit a neurotoxin and an apoptosis-inducing toxin from T. flavoviridis(Habu). In addition, the residues involved in the interactions between the antivenom-proteins and venomous proteins were investigated by mutantational and three-dimensional alalysis.
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