2011 Fiscal Year Final Research Report
Structural Studies on Signaling Mechanisms of General Stress Response in Bacillus Subtilis
| Project/Area Number |
22770142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | 島根県産業技術センター (2011)
Japan Synchrotron Radiation Research Institute (2010) |
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Principal Investigator |
MAKINO Masatomo 島根県産業技術センター, 機能性食品産業化プロジェクトチーム, 研究員 (30529582)
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| Project Period (FY) |
2010 – 2011
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| Keywords | シグナル伝達 / X線結晶学 / 枯草菌 / ストレス応答 |
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| Research Abstract |
Bacteria exploit signaling systems to respond to deleterious effects of stresses or sudden changes in the environment. In the case of Bacillus subtilis, stress information converges on and is transmitted to the general stress response transcription factorσ^B, leading to the expression of more than 200 general stress genes to exclude stresses or to repair the damage. In this study, I determined X-ray crystal structures of the N-terminal PAS domain and the C-terminal PPM-phosphatase domain of RsbP, an essential multi-domain protein required to activateσB in response to energy limitation.
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[Journal Article] Fine-needle capillary mounting for protein microcrystals
Author(s)
Makino, M., Wada, I., Mizuno, N., Shimizu, N., Hikima, T., Yamamoto, M., Kumasaka, T
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Journal Title
Peer Reviewed
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