2012 Fiscal Year Final Research Report
Structural analysis of Plasmodium falciparummalaria vaccine candidate antigen SERA5
| Project/Area Number |
22770151
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
YAGI Masanori 大阪大学, 微生物病研究所, 特任研究員 (60452463)
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| Project Period (FY) |
2010 – 2012
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| Keywords | タンパク質の物性 / マラリアワクチン |
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| Research Abstract |
Phase Ib clinical trial of malaria vaccine candidate SE36 in Uganda showed the safety of SE36 and possible protective effect against symptomatic malaria. However, no information has been reported on tertiary structure and physicochemical properties of SE36. This study revealed that the protective epitopes of SE36 have the characteristics of intrinsically unstructured regions and succeeded in construction of SE36 mutants suitable for structural analysis of SE36 antigen.
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[Journal Article] Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA52012
Author(s)
Tanabe K, Arisue N, Palacpac NM, Yagi M, Tougan T, Honma H, Ferreira MU, Farnert A, Bjorkman A, Kaneko A, Nakamura M, Hirayama K, Mita T, Horii T
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Journal Title
Vaccine
Volume: 30
Pages: 1583-1593
DOI
Peer Reviewed
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