2011 Fiscal Year Final Research Report
Elucidation of molecular mechanisms of ion-transporter proteins by using difference infrared spectroscopy
| Project/Area Number |
22770159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Institute for Molecular Science |
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Principal Investigator |
FURUTANI Yuji 分子科学研究所, 生命・錯体分子科学研究領域, 准教授 (80432285)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生体膜 / 受容体 / チャンネル |
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| Research Abstract |
Ion-transporter proteins, ion channels, and receptors in cell membrane work for production of biological energy, generation of bioelectric signal, and reception of external stimuli, respectively. To investigate the molecular mechanisms of these membrane proteins, we applied several methods of difference infrared spectroscopy on them, which provide structural information of biomolecules in action. The molecular mechanisms of microbial rhodopsins, V-type ATPase, and a potassium ion channel, KcsA, were partly elucidated based on the structural changes detected by our methods.
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