2012 Fiscal Year Final Research Report
Elucidating the molecular mechanisms of the centromere loading of CENP-A at G2 phase
| Project/Area Number |
22770176
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Teikyo University (2012)
Kurume University (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | セントロメア / 染色体構築 |
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| Research Abstract |
In fission yeast, it is thought that the incorporation of CENP-A at G2 phase may act as a rescue of the cell lethality. To identify factors that involved in the G2-loading pathway , we screened for multicopy suppressors of G2-loading deficient cells.Five candidate genes are isolated, and one of them has RNA binding motifs. A double mutant lacking both this RNA binding motif and ams2 genes exhibits synthetic lethality. In this study suggest that the factor may be important in centromere deposition of CENP-A at G2 phase.
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[Journal Article] Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible anstrand-specific ChIP-seq method2013
Author(s)
Zhou, ZX., Zhang, MJ., Peng, X., Takayama, Y., Xu, XY., Huang, LZ. Du, LL
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Journal Title
Genome Research
Volume: 23
Pages: 705-715
DOI
Peer Reviewed
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