2011 Fiscal Year Final Research Report
Study of GMF-based control of actin-meshwork organization during cell migration and endocytosis
| Project/Area Number |
22770184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞骨格 / アクチン / エンドサイトーシス / 分裂酵母 / メンブレントラフィック / Rho / Rab / 細胞性粘菌 |
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| Research Abstract |
Arp2/3 induces formation of actin meshwork which is required for membrane deformation in various type of cell movements. It has well been studied the molecular machinery activating Arp2/3 function. However, there is almost no study how Arp2/3-activity is down regulated during recycling of the actin cytoskeleton. Therefore, I decided to study the molecular function of a yeast homologue of the glia maturation factor GMF. Moreover, I tried to investigate cellular function of GmfA by using cellular mold which shows dynamic cell behavior.
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