2011 Fiscal Year Final Research Report
Regulation of stress granule formation by oxidative stress
| Project/Area Number |
22770188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | ストレスシグナル伝達 / ストレス顆粒 / ストレス応答MAPK経路 |
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| Research Abstract |
Stress granules(SGs) are phase-dense particles that appear in the cytoplasm of eukaryotic cells that have been exposed to environmental stress(e. g. arsenite, hypoxia). SGs play important role in cell survival. In this study, considering SGs as multifunctional structures, we searched for novel SG-associated proteins and identified USP10. Moreover, USP10 turned out to be important for maintaining the stability of SGs. Next, by observing SGs formation under multiple stress conditions, we found that formation of SGs was strongly inhibited under oxidative stress.
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