2011 Fiscal Year Final Research Report
Analysis for dual-step surveillance system in gene expression
| Project/Area Number |
22770198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SAKAKI Kenjiro 東京女子医科大学, 医学部, 講師 (70509968)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINA Sawako 東京女子医科大学, 医学部, 助教 (00424672)
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| Project Period (FY) |
2010 – 2011
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| Keywords | タンパク質分解 / 小胞体ストレス / 品質管理 / NMD |
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| Research Abstract |
Accuracy of gene expression is guaranteed by quality control systems that inspect their transcriptional or translational products at the multiple steps through the process of gene expression. And "interplays" of each quality control system give the adaptation of organs to diverse environmental changes and stress conditions. Herein, we revealed that nonsense-mediated RNA decay(NMD), one of RNA surveillance systems, significantly functions in ER quality control system(ERQC) that inspect folding status of secretive proteins in the endoplasmic reticulum(ER).
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[Journal Article] RNA surveillance is required for endoplasmic reticulum homeostasis
Author(s)
Sakaki, K., Yoshina, S., Shen, X., Han, J., DeSantis, MR., Xiong, M., Mitani S. and Kaufman, RJ.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: (in press)
Peer Reviewed
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[Journal Article] Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi
Author(s)
Yoshina, S., Sakaki, K., Yonezumi-Hayashi, A., Gengyo-Ando, K., Inoue, H., Iino, Y. and Mitani, S.
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Journal Title
Mol. Biol
Volume: (in press)
Peer Reviewed
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