2012 Fiscal Year Final Research Report
Mechanisms of the spindle assembly checkpoint silencing by kinetochore stretching
| Project/Area Number |
22770200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
UCHIDA Kazuhiko 公益財団法人がん研究会, がん研究所実験病理部, 研究員 (40380555)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞周期 / 紡錘体チェックポイント |
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| Research Abstract |
Kinetochore stretching, repetitive cycles of kinetochore extension and recoiling, inactivates the spindle assembly checkpoint after biorientation. At the same time, tension is applied across sister kinetochores by intact pulling force. It is thought that this tension also inactivates the checkpoint. In this study, I demonstrated that kinetochore stretching-dependent checkpoint silencing is independent from tension-dependent checkpoint silencing
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