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2011 Fiscal Year Final Research Report

Mechanisms of formation and maintenance of signaling center during brain patterning

Research Project

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Project/Area Number 22770206
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Masanori  東北大学, 大学院・医学系研究科, 助教 (20361074)

Project Period (FY) 2010 – 2011
Keywords(A)細胞分化
Research Abstract

In this study, I examined the processes of rhombomere-boundary formation in the Pax6 mutant rat hindbrain. This study suggests that Pax6 may repress neuronal differentiation through Notch signaling pathway in the rhombomere-boundary cells. I also analyzed cell behavior in the hindbrain of EphA4/ephrinB3b double knockdown-zebrafish embryos using high resolution-confocal time-lapse imaging. GFP^+ interface cells at r3/4 boundary abnormally elongated along the A-P axis and then migrated into r4 region, suggesting that EphA4/ephrinB3b signaling is required for sharpening rhombomere boundaries via regulation of cell migration and cell polarity.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates2012

    • Author(s)
      Tsunekawa, Y. Brutto, JM, Takahashi, M. Polleux, F. Tan, SS. Osumi, N.
    • Journal Title

      EMBO J

      Volume: Mar 6

    • Peer Reviewed
  • [Journal Article] Pax6 regulates rhombomere boundary cell specification in the rat hindbrain2011

    • Author(s)
      Takahashi, M. and Osumi, N.
    • Journal Title

      Mech

      Volume: Dev. 128 Pages: 289-302

    • Peer Reviewed
  • [Journal Article] The method of rodent whole embryo culture using the rotator-type bottle culture system2010

    • Author(s)
      Takahashi, M. and Osumi, N.
    • Journal Title

      J. Vis

      Volume: Exp. 42 Pages: 2170

    • Peer Reviewed
  • [Presentation] Pax6 regulates boundary cell specification in the rat hindbrain2011

    • Author(s)
      Takahashi, M. and Osumi, N.
    • Organizer
      The 1st Tohoku International Symposium on Multidisciplinary Neuroscience
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2011-01-21
  • [Presentation] Pax6 is involved in specification of rhombomere boundary cells in the rat hindbrain2010

    • Author(s)
      Takahashi, M. and Osumi, N.
    • Organizer
      3rd International Congress on Stem Cells and tissue Formation
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2010-07-13

URL: 

Published: 2013-07-31  

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