2011 Fiscal Year Final Research Report
A genome-wide analysis of let-7 micron-dependent developmental timing pathway
| Project/Area Number |
22770207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NIWA Ryusuke 筑波大学, 生命環境系, 助教 (60507945)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 発生・分化 / 発現制御 / 線虫 / 発生タイミング / マイクロRNA / 転写因子 / クロマチン構造制御因子 |
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| Research Abstract |
The development of multicellular organisms is tightly regulated under a precise time schedule. To unravel the molecular mechanisms underlying developmental timing in multicellular organisms, I used the nematode Caenorhabditis elegans as the model organism. I identified and characterized genes involved in the let-7 microRNA pathway, which is essential for the larva-to-adult transition. I found that the let-7 microRNA pathway is controlled by several transcription regulatory factors and receptor and chromatin-remodeling factors.
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