Wnt-dependent regulation of neuro-mesodermal precursor cells

2011 Fiscal Year Final Research Report

• Project/Area Number: 22770214
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Osaka University
• Principal Investigator: TAKEMOTO Tatsuya 大阪大学, 生命機能研究科, 助教 (30443899)
• Project Period (FY): 2010 – 2011
• Keywords: 胚葉形成 / 原腸形成 / 体節形成

Research Abstract

Vertebrate develops by addition of posterior tissues. It is well known that Wnt signal has an important role in this process. However, the mechanism of Wnt action in this process remains unknown.
I found that there is a common precursor cell deriving neural and mesodermal cell in the primitive streak region. Two transcription factors, SOX2 and TBX6, control the fate toward neural primordial cells and mesodermal cells, respectively. The expression of these genes is regulated by Wnt signal.

Research Products

• [Journal Article] Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells (2011)
  • Author(s): Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H
  • Journal Title: Nature Volume: 470(7334) Pages: 394-398
  • Peer Reviewed
• [Journal Article] The Pou5f1/ Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates (2011)
  • Author(s): Iwafuchi-Doi M, Yoshida Y, Onichtchouk D, Leichsenring M, Driever W, Takemoto T, Uchikawa M, Kamachi Y, Kondoh H
  • Journal Title: Dev Biol Volume: 352(2) Pages: 354-366
  • Peer Reviewed
• [Journal Article] B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos : Universal versus species-dependent features (2011)
  • Author(s): Uchikawa M, Yoshida M, Iwafuchi-Doi M, Matsuda K, Ishida Y, Takemoto T, Kondoh H
  • Journal Title: Dev Growth Differ Volume: 53(6) Pages: 761-771
  • Peer Reviewed
• [Presentation] Tbx6-dependent regulation of Sox2 determines neural versus mesodermal fate in axial stem cells (2011)
  • Author(s): Tatsuya Takemoto
  • Organizer: 3rd international Sox meeting
  • Place of Presentation: Grainau Germany
  • Year and Date: 2011-09-10
• [Presentation] Tbx6-dependent regulation of Sox2 determines neural versus mesodermal fate in axial stem cells (2011)
  • Author(s): Tatsuya Takemoto, Masanori Uchikawa, Megumi Yoshida, Donald Bell, Robin Lovell-Badge, Virginia Papaioannou, Hisato Kondoh
  • Organizer: 44th Annual Meeting for JSDB
  • Place of Presentation: OKINAWA
  • Year and Date: 2011-05-20
• [Presentation] Tbx6-dependent regulation of Sox2 enhancer N1 determines the neural vs. mesodermal fate of axial stem cells in the caudal lateral epiblast (2010)
  • Author(s): Tatsuya Takemoto, Masanori Uchikawa, Robin Lovell-Badge, Virginia E. Papaioannou and Hisato Kondoh
  • Organizer: Society for Developmental Biology 69^<th> Annual Meeting
  • Place of Presentation: Albuquerque, USA
  • Year and Date: 20100805-09
• [Presentation] Enhancer N-1-dependent activation of Sox2during caudal extension of the neural plate and its downstream molecular events (2010)
  • Author(s): Megumi Yoshida, Tatsuya Takemoto Masanori Uchikawa, Hisato Kondoh
  • Organizer: Society for Developmental Biology 69th Annual Meeting
  • Place of Presentation: Albuquerque, USA
  • Year and Date: 20100805-09
• [Presentation] A gene regulatory network that underlies the derivation of the anterior neural plate from the epiblast (2010)
  • Author(s): Makiko Iwafuchi-Doi, Tatsuya Takemoto, Yuzo Yoshida, Isao Matsuo, Jun Aruga, Yusuke Kamachi, Masanori Uchikawa, Hisato Kondoh
  • Organizer: Society for Developmental Biology 69^<th> Annual Meeting
  • Place of Presentation: Albuquerque, USA
  • Year and Date: 20100805-09
• [Book] Tbx6に依存したSox2遺伝子の制御が,体軸幹細胞の神経系と中胚葉への発生運命を決定する (2011)
  • Author(s): 竹本龍也, 近藤寿人
  • Total Pages: 744-745
  • Publisher: 学研メディカル秀潤社
• [Remarks] 毎日新聞「同一細胞から神経や筋肉」2011年02月17日(木)報道関連情報
• [Remarks] 日本経済新聞「神経形成に命令遺伝子理研が脳、阪大は脊髄で解明」2011年02月17日(木)報道関連情報
• [Remarks] 読売新聞「教科書の定説覆る神経と筋肉同じ細胞から発生」2011年02月17日(木)報道関連情報
• [Remarks] 産経新聞「中枢神経と骨・筋肉共通細胞から阪大など国際チーム」2011年02月17日(木)産経新聞「中枢神経と骨・筋肉共通細胞から阪大など国際チーム」2011年02月17日(木)報道関連情報
• [Remarks]
  • URL: http://first.lifesciencedb.jp/archives/2319
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/kondoh/Kondoh_Lab/Welcome.html