2011 Fiscal Year Final Research Report
Molecular evolution of ancient TIR containing gene family in innate immunity
| Project/Area Number |
22770232
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Evolutionary biology
|
|---|
| Research Institution | Saitama University |
|---|
Principal Investigator |
HIBINO Taku 埼玉大学, 教育学部, 准教授 (60513835)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | Toll-like receptor / ウニ / ウミユリ / 棘皮動物 / 自然免疫 |
|---|
| Research Abstract |
To unveil a repertoire of Toll-like receptors (TLRs) and TIR containing signaling molecules in a basal deuterostome, we analyzed EST of a stalked crinoid, Metacrinus rotundas, whose embryonic and larval cDNA have been sequenced by Next Gene Sequencing. So far, we identified 6 TLRs that consist of 3 genes of fly-type and 3 genes of vertebrate type TLRs. MyD88-like genes and Sarm-like genes were also identified in the cDNA of the sea lily, suggesting these genes exist in a basal deuterostome. We found unique TIR containing gene families, CARD-TIR and TPR-TIR, in the sequencing data of the sea lily, which have not been in the genome of the sea urchin, but in that of amphioxus. These data suggest a basal deuterostome could utilize multigenes of TLRs and various types of TIR containing genes. And the refinement of TLRs and signaling molecules could happen after the appearance of acquired immunity.
|
-
-
-
-
-
[Remarks] アウトリーチ活動日比野拓,他キッズユニバーシティ「ゲームで知ろう!海の危険な生物」埼玉大学教育学部2011年12月28日上記のアウトリーチ活動のマスメディア報道
-
[Remarks] 東京新聞地方版インタビュー記事掲載2011年12月31日
-
[Remarks] テレ玉イブニングNEWSイベントの様子を紹介2011年12月28日
