2011 Fiscal Year Final Research Report
Cell cycle-related protein kinases in Aspergillus fumigatus
| Project/Area Number |
22780079
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
UMEYAMA Takashi 国立感染症研究所, 生物活性物質部, 主任研究官 (20360696)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 微生物制御学 |
|---|
| Research Abstract |
Overall mortality with invasive pulmonary aspergillosis was over 50%, leading to strong expectation for development of a novel therapeutics. Aim of study is to elucidate correlation between cell cycle regulation and filamentous growth via analysis of protein kinases in Aspergillus fumigatus, the major causative agent of aspergillosis. I analyzed 4 protein kinases by inhibitors, gene disruption, gene downregulation, and chemical genetics. I found that Aukl and Mps 1 are essential for the growth. These results could contribute to basic research for a novel therapeutics of aspergillosis and give a new insight of unique mechanism for cell cycle regulation into basic biology field.
|
Research Products
(7 results)
