2011 Fiscal Year Final Research Report
Analysis of carbohydrate recognition by Pradimicins, natural small molecules with lectin-like properties
| Project/Area Number |
22780109
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
NAKAGAWA Yu 独立行政法人理化学研究所, 伊藤細胞制御化学研究室, 専任研究員 (90452284)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | Antibiotic / Carbohydrate recognition / Lectin / Natural product / Pradimicin / Solid-state NMR |
|---|
| Research Abstract |
Pradimicins(PRMs) are natural antibiotics that recognize D-mannose(Man) in the presence of Ca^<2+> ion. In this study, a new strategy for analyzing molecular interaction of PRMs with Man in the solid state has been developed. The solid-state NMR analyses of the complexes of PRMs with Man revealed that PRMs bind Man in a Ca^<2+>-mediated manner, and successfully identified the Man binding site of PRMs.
|
-
-
[Journal Article] Solid-state NMR analysis of calcium and D-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A2012
Author(s)
Nakagawa, Y., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
-
Journal Title
Bioorg. Med. Chem. Lett.
Volume: 22
Pages: 1038-1041
Peer Reviewed
-
[Journal Article] Mapping of the Primary Mannose-Binding Site of Pradimicin A2011
Author(s)
Nakagawa, Y., Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., and Ito, Y.
-
Journal Title
J. Am. Chem. Soc.
Volume: 133
Pages: 17485-17493
Peer Reviewed
-
[Journal Article] Solid-state NMR Spectroscopic Analysis of the Ca^<2+>-dependent Mannose Binding of Pradimicin A2011
Author(s)
Nakagawa, Y., Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
-
Journal Title
Angew. Chem. Int. Ed.
Volume: 50
Pages: 6084-6088
Peer Reviewed
-
-
-
-
-
-
