2012 Fiscal Year Final Research Report
Regulation of immune state in adipose tissue associated with life style diseases by food components
| Project/Area Number |
22780111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Chiba University |
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Principal Investigator |
HIRAI Shizuka 千葉大学, 大学院・園芸学研究科, 助教 (90432343)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肥満 / 免疫環境 / マスト細胞 / カロテノイド / 脂肪細胞分化 |
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| Research Abstract |
In the present study, I clarified the immune cells infiltrated into adipose tissues in the progression of obesity, and explored the food components which can improve the immune state in obese adipose tissues. As a result, T cells and mast cells, as well as macrophages, were infiltrated into obese adipose tissues, and I found the involvement of mast cells in fibrosis of obese adipose tissues. I further demonstrated that food-derived carotenoids, astaxanthin and canthaxanthin, could improve glucose intolerance in obese mice by the inhibition of adipocyte differentiation, which suppressed the aggravation of immune state in obese adipose tissues.
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