2011 Fiscal Year Final Research Report
Biological functions and mechanisms of vitamin D action on bone and mineral metabolism
| Project/Area Number |
22780114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAMOTO Yoko 東京大学, 分子細胞生物学研究所, 特任研究員 (30376644)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ビタミンD / VDR / 骨代謝 / カルシウム代謝 / 転写制御 / 遺伝子改変マウス / 栄養化学 |
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| Research Abstract |
The present study aims to find out biological functions and mechanisms of vitamin D action on bone and mineral metabolism. Osteoblast-specific VDRKO mice exhibited increased bone mass. These data indicated that VDR in osteoblasts is a negative regulator of bone mass control. Unlike systemic-VDRKO mice, AF-2 domain deleted VDR knock-in mice fed with high calcium diet exhibited hypocalcemia and impaired bone formation. These data indicated that unliganded VDR exerted negative effects on bone formation and mineral metabolism.
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