Study of a novel regulatory mechanism for the control of adipocyte functions by amino acids

2011 Fiscal Year Final Research Report

• Project/Area Number: 22780116
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Kyoto University (2011); Gifu University (2010)
• Principal Investigator: GOTO Tsuyoshi 京都大学, 生理化学研究ユニット, 特定助教 (10550311)
• Project Period (FY): 2010 – 2011
• Keywords: 食品機能 / 脂肪細胞 / 分岐鎖アミノ酸 / ロイシン / 肥満

Research Abstract

In the absence of insulin, leucine, one of branched-chain amino acids, suppresses triglyceride accumulation via the inhibition of glucose uptake in adipocytes, whereas it promotes the uptake of fatty acids in adipocytes in the presence of insulin. Moreover, the treatment for obese mice with leucine seems to improve the carbohydrate metabolism. These results indicated that leucine regulates whole body energy metabolism by the action on the organs, including white adipose tissue, depending on the nutrient state.

Research Products

• [Journal Article] Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and-independent pathways (2011)
  • Author(s): Goto T, Kim YI, Funakoshi K, Teraminami A, Uemura T, Hirai S, Lee JY, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Takahashi N, Kawada T.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 301(5) Pages: E1022-E1032
  • DOI: DOI:10.1152/ajpendo.00061.2011
  • Peer Reviewed
• [Journal Article] Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγagonist (2011)
  • Author(s): Goto T, Nagai H, Egawa K, Kim YI, Kato S, Taimatsu A, Sakamoto T, Ebisu S, Hohsaka T, Miyagawa H, Murakami S, Takahashi N, Kawada T.
  • Journal Title: Biochem J. Volume: 438(1) Pages: 111-119
  • DOI: DOI:10.1042/BJ20101939
  • Peer Reviewed
• [Journal Article] Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes (2011)
  • Author(s): Goto T, Lee JY, Teraminami A, Kim YI, Hirai S, Uemura T, Inoue H, Takahashi N, Kawada T.
  • Journal Title: J Lipid Res Volume: 52(5) Pages: 873-884
  • DOI: DOI:10.1194/jlr.M011320
  • Peer Reviewed
• [Journal Article] Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice
  • Author(s): Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, Hirai S, Uemura T, Yu R, Takahashi N, Kawada T.
  • Journal Title: J Nutr Biochem Volume: (in press)
  • DOI: DOI:10.1016/j.jnutbio.2011.04.001
  • Peer Reviewed
• [Presentation] イソプレノイドによるエネルギー代謝調節機構 (2012)
  • Author(s): 後藤剛、高橋信之、河田照雄
  • Organizer: 農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-25
• [Presentation] Phytolおよびその代謝物が糖・脂質代謝異常に及ぼす影響農芸化学会 (2012)
  • Author(s): 安芝英、後藤剛、高橋春弥、永井宏幸、金英一、高橋信之、河田照雄
  • Organizer: 2012年度大会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-24
• [Presentation] ファルネシル二リン酸は内因性PPARγアゴニストとして、脂肪細胞機能を調節する (2011)
  • Author(s): 後藤剛、永井宏幸、江川香、金英一、加藤壮太、泰松暁、坂本智弥、恵比須省吾、方坂貴弘、高橋信之、河田照雄
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-09-23
• [Presentation] ローズヒップポリフェノール(tiliroside)の腸管における糖質代謝改善作用機構の解析 (2011)
  • Author(s): 後藤剛、堀田真由香、西田典久、長友暁史、松浦洋一、長岡利
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学
  • Year and Date: 2011-05-15
• [Book] 日本臨牀2011年増刊号-メタボリックシンドローム(第2版):3.メタボリックシンドローム発症基盤としての脂肪細胞機能異常1)脂肪細胞のライフサイクルとその制御因子 (2011)
  • Author(s): 後藤剛、李周容、高橋信之、河田照雄
  • Total Pages: 201-205
  • Publisher: 日本臨牀社
• [Remarks]
  • URL: http://www.foodfunc.kais.kyoto-u.ac.jp/index.html