2012 Fiscal Year Final Research Report
Searching for fatty liver susceptible genes under high-fat diet: by using congenic mice.
| Project/Area Number |
22780118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 高脂肪食 / 脂質代謝 / トリグリセリド / 脂肪肝 / 責任遺伝子 |
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| Research Abstract |
We previously mapped the fatty liver susceptible locus (fl1sa) on mouse chromosome 12 by using SMXA-5, a mouse model for fatty liver induced by a high-fat diet feeding. We searched a responsible gene causing the fatty liver . In this study, we found that one candidate gene suppress the triglyceride synthesis in hepatocytes. This result suggests that the candidate gene coding protein is a new molecule regulating hepatic lipid metabolism.
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[Journal Article] Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 142010
Author(s)
Babaya N, Fujisawa T, Nojima K, Itoi-Babaya M, Yamaji K, Yamada K, Kobayashi M, Ueda H, Hiromine Y, Noso S, Ikegami H
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Journal Title
Diabetologia
Volume: 52
Pages: 1362-1371
DOI
Peer Reviewed
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