2011 Fiscal Year Final Research Report
Regulation of dopamine function by amino acid intake via modulation of tryptophan metabolism
| Project/Area Number |
22780123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Shiga Prefecture |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 栄養学 / 脳・神経 / 食品 |
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| Research Abstract |
The purpose of this study is to obtain findings for maintain brain function by diet. In vivo and in vitro, intake of branched chain amino acids, leucine or isoleucine suppressed production of tryptophan metabolite kynurenic acid, and enhanced release of neurotransmitter dopamine in rat brain. These results suggest that dietary manipulation of kynurenic production can modulate dopamine release in normal rage.
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