2011 Fiscal Year Final Research Report
Identification and characterization of protein bindingto pyrroloquinoline quinone (PQQ), a vitamin-like substance
| Project/Area Number |
22780124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
AKAGAWA Mitsugu 大阪府立大学, 生命環境科学研究科, 講師 (70405356)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Takeshi 静岡県立大学, 大学院・生活健康科学研究科, 助教 (50448700)
TANI Shuji 大阪府立大学, 大学院・生命環境科学研究科, 講師 (80405357)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ピロロキノリンキノン / ビタミン / 酸化還元補酵素 / キノン / 機能性食品因子 |
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| Research Abstract |
Pyrroloquinoline quinone (PQQ), a redox cofactor for bacterial dehydrogenases, has been implicated to be an important nutrient or vitamin in mammals functioning. In the present study, to investigate the potential of PQQ as vitamin, we searched for PQQ-binding protein in mouse NIH3T3 fibroblasts. We found cytoskeletal proteins, heat shock protein families, carbohydrate metabolic enzyme, and glycolytic enzyme as novel PQQ-binding proteins.
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[Journal Article] Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-Aymice2012
Author(s)
Takada, M., Sumi, M., Maeda, A., Watanabe, F., Kamiya, T., Ishii, T., Nakano, M., and Akagawa, M
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 428
Pages: 315-320
Peer Reviewed
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