2011 Fiscal Year Final Research Report
Telomerase inhibition by carotenoid and its synergistic effect of other constituents in food stuffs.
| Project/Area Number |
22780126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | テロメラーゼ / カロテノイド / 相乗効果 |
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| Research Abstract |
We screened potential telomerase inhibitors in food stuffs, and found that β-carotene, the most common carotenoid, significantly inhibited telomerase in cell-culture study. After treatment of the cells with β-carotene and vitamin E(α-tocopherol), telomerase activity was synergistically reduced. Furthermore, we ascertained the anti-telomerase action of β-carotene using in vivo tumor models.
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[Journal Article] Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of simian vacuolating virus 40 large T fragment2012
Author(s)
T. Fukuda, M. Katayama, T. Yoshizawa, T. Eitsuka, H. Mizukami, K. Nakagawa, H. Ito, H. Komagata, S. Song, S. Roh, Y. Hoshino, E. Sato, H. Hanada, K. Nishimori, T. Miyazawa, T. Uchida
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Journal Title
Biosci. Biotech. Biochem
Volume: (in press)
Peer Reviewed
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