2011 Fiscal Year Final Research Report
Identification and assessment of probiotic factor(s) via multiple omics approach.
| Project/Area Number |
22780132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUKUDA Shinji 独立行政法人理化学研究所, 免疫系構築研究チーム, 研究員 (80435677)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ビフィズス菌 / 酢酸 / O157 / マルチオーミクス / プロバイオティクス / 腸内細菌 / 相互作用 / 病原性大腸菌 |
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| Research Abstract |
In order to demonstrate the effect of the bifidobacterial genes encoding 'probiotic transpoter', we generated the genes deficient or overexpressing bifidobacterial strains and assessed them using Escherichia coli O157 : H7 lethal infection murine model. Our experiments clearly showed that the 'probiotic transpoter' largely contributes to the production of acetate by colonized bifidobacteria in the murine colon, and it could prevent the inflammation provoked by Escherichia coli O157 : H7 infection.
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Research Products
(27 results)
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[Journal Article] Bifidobacteria can protect from enteropathogenic infection through production of acetate2011
Author(s)
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., and Ohno, H
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Journal Title
Nature
Volume: 469
Pages: 543-547
Peer Reviewed
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[Journal Article] A dynamic omics approach identifies nutrition-mediated microbial interactions2011
Author(s)
Nakanishi, Y., Fukuda, S., Chikayama, E., Kimura, Y., Ohno, H., and Kikuchi, J
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Journal Title
J. Proteome Res
Volume: 10
Pages: 824-836
Peer Reviewed
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[Journal Article] The epithelia-specific membrane trafficking factor AP-1B secures gut immune homeostasis in mice2011
Author(s)
Takahashi, D., Hase, K., Kimura, S., Nakatsu, F., Ohmae, M., Mandai, Y., Sato, T., Date, Y., Ebisawa, M., Kato, T., Obata, Y., Fukuda, S., Kawamura, Y., Dohi, T., Katsuno, T., Yokosuka, O., Waguri, S., and Ohno, H.
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Journal Title
Gastroenterology
Volume: 141
Pages: 621-632
Peer Reviewed
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[Journal Article] Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation2011
Author(s)
Prakash, T., Oshima, K., Morita, H., Fukuda, S., Imaoka, A., Kumar, N., Sharma, V. K., Takahashi, M., Saitou, N., Taylor, T. D., Ohno, H., Umesaki, Y., and Hattori, M.
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Journal Title
Cell Host Microbe
Volume: 10
Pages: 273-284
Peer Reviewed
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[Journal Article] Bifidobacterium kashiwanohaense sp. nov., isolated from healthy infant faeces2011
Author(s)
Morita, H., Nakano, A., Onoda, H., Toh, H., Oshima, K., Takami, H., Murakami, M., Fukuda, S., Takizawa, T., Kuwahara, T., Ohno, H., Tanabe S., and Hattori, M.
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Journal Title
Int. J. Syst. Evol.Microbiol
Volume: 61
Pages: 2610-2615
Peer Reviewed
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[Journal Article] Development of a monitoring approach for metabolic dynamics in microbial ecosystems by stable isotope labeling technologies2010
Author(s)
Date, Y., Nakanishi, Y., Fukuda, S., Kato, T., Tsuneda, S., Ohno, H., and Kikuchi, J.
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Journal Title
J. Biosci. Bioeng
Volume: 110
Pages: 87-93
Peer Reviewed
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[Presentation] Bifidobacteria can protect from enteropathogenic infection through production of acetate2012
Author(s)
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clark, JM., Topping, DL., Suzuki, T., Taylor, TD., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., Ohno, H.
Organizer
Keystone Symposia
Place of Presentation
The Microbiome, Keystone, Colorado
Year and Date
2012-03-05
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[Presentation] Bifidobacteria can protect from enteropathogenic infection through production of acetate2011
Author(s)
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clark, JM., Topping, DL., Suzuki, T., Taylor, TD., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., Ohno, H
Organizer
Keystone Symposia : Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines
Place of Presentation
New Delhi
Year and Date
2011-11-09
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[Presentation] Integrated omics approach identified acetate produced by probiotic bifidobacteria to protect host from enteropathogenic infection2011
Author(s)
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clark, JM., Topping, DL., Suzuki, T., Taylor, TD., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., Ohno, H
Organizer
15th International Congress of Mucosal Immunology
Place of Presentation
Paris
Year and Date
2011-07-07
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[Presentation] Multiple omics identified probiotic bacterial metabolites to prevent gut inflammation provoked by enterohemorrhagic Escherichia coli O157 : H7 infection2010
Author(s)
Fukuda、S., Toh, H., Nakanishi, Y., Hase, K., Oshima, K., Yoshimura, K., Tobe, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., Ohno, H
Organizer
14th International Congress of Immunology
Place of Presentation
Kobe
Year and Date
2010-08-26
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