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2011 Fiscal Year Final Research Report

Functional analysis of Foxo1 and PPRA. possibly involved in the species-specific lipid accumulation of fish

Research Project

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Project/Area Number 22780190
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

KANEKO Gen  東京大学, 大学院・農学生命科学研究科, 助教 (30466809)

Project Period (FY) 2010 – 2011
Keywords代謝・酵素 / 脂質蓄積
Research Abstract

We cloned the full open reading frame of Foxo1 from torafugu. The transcripts were widely distributed in various tissues. Like the mammalian orthologues, torafugu Foxo1 protein was excluded from nucleus in a insulin-like growth factor I(IGF-I)-dependent manner, and bound to peroxisome proliferator-activated receptorγ(PPARγ) in vitro. On the other hand, the mRNA levels of PPARγand its putative target, lipoprotein lipase(LPL), showed a good correlation with the lipid content of liver and muscle in torafugu and red seabream. These results suggest that PPARγpromotes the species-specific lipid accumulation in fish, and Foxo1 functions as an IGF-dependent inhibitor of PPARγ.

  • Research Products

    (15 results)

All 2012 2011 2010

All Journal Article (5 results) Presentation (9 results) Book (1 results)

  • [Journal Article] cDNA cloning and primary structure analysis of transglutaminase from bluefin tuna Thunnus orientalis2012

    • Author(s)
      Ikeguchi K, Kaneko G, Watabe S
    • Journal Title

      Fish Sci

      Volume: 78 Pages: 667-674

  • [Journal Article] Correlation with larval body size of mRNA levels of growth hormone, growth hormone receptor I and insulin-like growth factor I in larval torafugu Takifugu rubripes.2011

    • Author(s)
      Kaneko G^*, Furukawa S^*, Kurosu Y, Yamada T, Takeshima H, Nishida M, Mitsuboshi T, Otaka T, Shirasu K, Koda T, Takemasa Y, Aki S, Mochizuki T, Fukushima H, Fukuda Y, Kinoshita S, Asakawa S, Watabe S
    • Journal Title

      J. Fish Biol

      Volume: 79 Pages: 854-874

  • [Journal Article] cDNA cloning of two types of growth hormone receptor in torafugu Takifugu rubripes : tissue distribution is possibly correlated to lipid accumulation patterns2011

    • Author(s)
      Hirano Y, Kaneko G, Koyama H, Ushio H, Watabe S
    • Journal Title

      Fish. Sci

      Volume: 77 Pages: 855-865

  • [Journal Article] EST analysis on adipose tissue of rainbow trout Oncorhynchus mykiss and tissue distribution of adiponectin2011

    • Author(s)
      Kondo H, Suga R, Suda S, Hirono I, Nagasaka R, Kaneko G, Ushio H, Watabe S.
    • Journal Title

      Gene

      Volume: 485 Pages: 40-45

  • [Journal Article] Constitutive expression of insulin receptor substrate(IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts2011

    • Author(s)
      Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi SI
    • Journal Title

      PLoS ONE

      Volume: 6 Pages: e25655

  • [Presentation] マダイ14kDaアポリポタンパク質のcDNAクローニングおよび血漿成分の電気泳動分析2012

    • Author(s)
      金子元,白神裕人,潮秀樹,渡部終五
    • Organizer
      平成24年度日本水産学会春季大会
    • Place of Presentation
      東京
    • Year and Date
      20120326-30
  • [Presentation] Studies on the species-specific lipid accumulation in torafugu and red seabream2011

    • Author(s)
      Kaneko G
    • Organizer
      The International Symposium on Muscle Biochemistry
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20111027-29
  • [Presentation] 発現配列タグ(EST)を利用したトラフグおよびマダイのアポリポタンパク質の発現様式の比較2011

    • Author(s)
      金子元,近藤秀裕,廣野育生,長阪玲子,佐藤秀一,潮秀樹,渡部終五
    • Organizer
      平成23年度日本水産学会秋季大会
    • Place of Presentation
      長崎
    • Year and Date
      20110928-1002
  • [Presentation] Effects of feed restriction on gene expression profiles of adiponectin and related signal transduction molecules associated with energy metabolism in rainbow trout Oncorhynchus mykiss muscle2011

    • Author(s)
      Kondo H, Suda S, Kawana Y, Hirono I, Nagasaka R, Kaneko G, Ushio H, Watabe S
    • Organizer
      Genomics in Aquaculture International Symposium
    • Place of Presentation
      Crete, Greece
    • Year and Date
      20110914-17
  • [Presentation] トラフグおよびマダイの脂質分布とリポタンパク質リパーゼ遺伝子の発現様式2011

    • Author(s)
      金子元,山田敏弘,平野雪,白神裕人,潮秀樹,渡部終五
    • Organizer
      平成23年度日本水産学会春季大会
    • Place of Presentation
      東京(東日本大震災のため口頭発表中止)
    • Year and Date
      20110300
  • [Presentation] 環境馴致による魚類筋肉の生化学的変化2011

    • Author(s)
      金子元,渡部終五
    • Organizer
      日本水産学会シンポジウム企画委員会主催シンポジウム漁獲物の蓄養による品質向上技術
    • Place of Presentation
      長崎
    • Year and Date
      2011-09-28
  • [Presentation] Expressed sequence tag analysis of liver and fast muscle from red seabream Pagrus major in relation to lipid metabolism2010

    • Author(s)
      Kaneko G, Kondo H, Hirono I, Nagasaka R, Satoh S, Ushio H, Watabe S
    • Organizer
      9th International Marine Biotechnology Symposium
    • Place of Presentation
      Qingdao, China
    • Year and Date
      20101008-12
  • [Presentation] Continuous activation of IGF signaling inhibits myogenic differentiation of L6 myoblasts2010

    • Author(s)
      Hakuno F, Kaneko G, Yamauchi Y, Chida K, Nakae J, Takahashi SI
    • Organizer
      5th International Congress of the GRS and the IGF Society
    • Place of Presentation
      New York, NY, USA
    • Year and Date
      20101003-07
  • [Presentation] Molecular characterization of forkhead transcription factor O1(FoxO1) from torafugu Takifugu rubripes in relation to lipid metabolism2010

    • Author(s)
      Zhang W, Kaneko G, Ushio H, Watabe S
    • Organizer
      2010(平成22)年度日本水産学会秋季大会
    • Place of Presentation
      京都
    • Year and Date
      2010-09-23
  • [Book] 魚類のエネルギー代謝に及ぼす水温および飢餓の影響.福田裕・渡部終五編沿岸漁獲物の高品質化2012

    • Author(s)
      金子元,潮秀樹,渡部終五
    • Total Pages
      25-34
    • Publisher
      恒星社厚生閣

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Published: 2013-07-31  

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