2011 Fiscal Year Final Research Report
Physiological roles of ARF1 mRNA interacting with insulin receptor substrates
| Project/Area Number |
22780249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | Hiroshima University (2011)
The University of Tokyo (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 代謝 / 内分泌制御 |
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| Research Abstract |
We have previously found that insulin receptor substrates(IRSs), mediators of insulin/ insulin-like growth factors(IGFs) signals, are associated with RNA. In this study, we investigated roles of the complexes. Results suggest that IRSs play multiple roles ; 1) they promote small nucleolar RNA(snoRNA) biogenesis, leading to enhanced ribosomal maturation/ activation, and 2) they regulate internal ribosome entry site(IRES)-mediated translation.
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