2012 Fiscal Year Final Research Report
Studies on virus-host interaction and innate immunity involved in the persistent infection of bovine viral diarrhea virus
| Project/Area Number |
22780265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
AOKI Hiroshi 日本獣医生命科学大学, 獣医学部, 准教授 (10440067)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 牛ウイルス性下痢ウイルス / 自然免疫 / 干渉現象 / 持続感染 |
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| Research Abstract |
Noncytopathogenic bovine viral diarrhea virus could be classified to two biotypes, and each virus had existed together in a viral strain. One biotype could up-regulate the innate immunity of host cells, but the other suppressed it. The specific biological property of each virus was reciprocally interfered in the cells co-inoculated with the viruses, but the innate immunity of these cells was activated at various levels while being influenced from control of each virus. Co-infection of these viruses might involve in the persistent infection.
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