2012 Fiscal Year Final Research Report
A molecular and epidemiological study on myopericytoma in cattle and its association with bovine papillomavirus infection.
| Project/Area Number |
22780272
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
HATAMA Shinichi 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・寒地酪農衛生研究領 域, 主任研究員 (50360623)
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| Co-Investigator(Renkei-kenkyūsha) |
AKASHI Hiroomi 国立大学法人東京大学, 農学生命科学研究 科, 教授 (10334327)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 牛パピローマウイルス / 筋血管周皮腫 / 牛乳頭腫症 / E2 / bTax1BP1 |
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| Research Abstract |
We represented epidemiological evidence for bovine papillomavirus (BPV) type 1 infection of a benign tumor, myopericytoma, in cattle. Molecular mechanisms of myopericytoma formation were also analyzed. We revealed that protein-protein interaction with the virus-encoded transcriptional regulator, E2, and host cell-derived transcriptional coactivator, bTax1BP1, plays an important role in thetranscriptional activation of the BPV promoter.
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