2011 Fiscal Year Final Research Report
Clarification of unaccountable mechanisms in novel canine neutrophil dysfunction to find new treatment
| Project/Area Number |
22780277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 家族性好中球機能不全症 / β2-インテグリン / 犬 / ウシラクトフェリン / CD11b/CD18 |
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| Research Abstract |
We found a mixed-breed male dog with novel familial neutrophil dysfunction. The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation, followed by a profound decrease of superoxide production. Our results indicate that oral treatment with bovine lactoferrin increases neutrophil β2-integrin transcript level, leading to the up regulation of neutrophil functions and improvement of clinical symptoms in the dog with familial neutrophil dysfunction.
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Research Products
(3 results)
