2011 Fiscal Year Final Research Report

Detection of a defense system of intestinal mucosa as a novel examination tool for canine inflammatory bowel disease

Research Project

Project/Area Number	22780279
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Clinical veterinary science
Research Institution	Tokyo University of Agriculture and Technology
Principal Investigator	IDE Kaori 東京農工大学, 大学院・農学研究院, 助教 (40550281)
Project Period (FY)	2010 – 2011
Keywords	犬 / 炎症性腸疾患 / 腸管型アルカリフォスファターゼ / 腸管粘膜上皮
Research Abstract	Intestinal alkaline phosphatase (iALP) was found to be expressed with enzymatic activity, more intensively in mucosal epithelia of duodenum than of colon, in dogs. Dephosphorylation reaction of lipopolysaccharide (LPS), which is the core function of the defense mechanism by iALP against excessive intestinal microflora, was also proven to be active. Fecal iALP concentration was shown to be high in cases of severe inflammatory bowel disease with high clinical activity score.

(2 results)