2011 Fiscal Year Final Research Report
Synthesis of cyclodepsipeptide using organic catalysts
| Project/Area Number |
22790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 環状デプシペプチド / 有機合成 / 有機触媒 / 不斉合成 |
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| Research Abstract |
We have been working on the synthesis of functionalized amino acids and naturally occurring cyclodepsipeptides. As part of this research, we would develop an organocatalytic enantioselective synthesis of unusual amino acids. Homophimin A and lydiamycin A were selected as target compouds for this purpose. We have synthesized all constituents of homophimie A and the cyclic part of homophimine A. In the synthesis of lydiamycin A, piperazic acid was stereoselectively synthesized with proline catalyzed hydrazination. We have achieved the synthesis of the proposed structure of lydiamycin A.
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