2012 Fiscal Year Final Research Report
Catalytic and Enantioselective Construction of Cyclohexane-fused Heterocycles
| Project/Area Number |
22790007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
HARADA Shinji 千葉大学, 大学院・薬学研究院, 助教 (10451759)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 不斉合成 / 合成化学 / 不斉触媒 / ヒドロカルバゾール / 多環性骨格構築 |
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| Research Abstract |
The cycloaddition between siloxyvinyl-indole and dienophile gave hydrocarbazoles in up to quant. and 93% ee by using a novel chiral Thulium(III) catalyst. Synthetic application of adducts to biologically active compounds was also performed. It is noteworthy that this reaction system could be extendable to other heteroaromatic compounds.
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