2011 Fiscal Year Final Research Report
Development of a recapturable linker that enables isolation and labeling of target proteins
| Project/Area Number |
22790012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHIGENAGA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10423394)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アビジン / 蛋白質精製 / 蛋白質ラベル化 / ビオチン / プルダウン / ペプチド / ペプチド結合切断 / 有機合成化学 |
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| Research Abstract |
In the field of proteomics, methodology of isolation followed by selective labeling of target proteins is indispensable. Therefore, we decided to develop a" Recapturable Linker" that enables isolation and selective labeling of the target proteins. As a result, the" Recapturable Linker" was synthesized and it was successfully applied to selective labeling of a model peptide of the target protein.
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