2011 Fiscal Year Final Research Report
Search for hepatoprotective constituents by reductive effect of sensitivity to TNF-αfrom medicinal plants
| Project/Area Number |
22790026
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生薬 / 天然物化学 |
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| Research Abstract |
In order to investigate hepatoprotective constituents by reductive effect of sensitivity to TNF-αfrom medicinal plants, we examined inhibitory effect on TNF-α-induced cytotoxicity in L929 cells as a first screening trial. As the results, several materials such as Thai medicinal plants, Piper chaba(fruit), Sapindus rarak(pericarps), Kaempferia parviflora(rhizomes), Shorea roxburghii(bark), and Mammea siamensis(flowers) and Cistanche tubulosa(stems) were found to inhibit the activity. From those candidate materials, several constituents were investigated as the active compounds. Furthermore, the structural requirements and the mode of action of the active compounds were also examined.
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[Journal Article] Iridoid and acyclic monoterpene glycosides, kankanosides L, M, N, O, and P from Cistanche tubulosa2010
Author(s)
Morikawa T., Pan Y., Ninomiya K., Imura K., Yuan D., Yoshikawa M., Hayakawa T. Muraoka O.
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Journal Title
Chem. Pharm. Bull.
Volume: 58
Pages: 1403-1407
Peer Reviewed
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[Presentation] Anti-inflammatory effects and mode of action of prenylcoumarins from the flower buds of Mammea siamensis2011
Author(s)
Morikawa T., Chaipech S., Sueyoshi M., Matsuda H., Nomura Y., Umeyama M., Yabe M., Sakakibara R., Matsumoto T., Hikita T., Ninomiya K., Yoshikawa M., Mukai H., Kiso Y., Pongpiriyadacha Y., Muraoka O.
Organizer
8th AFMC International Medicinal Chemistry Symposium(AIMECS11)
Place of Presentation
Keio Plaza Hotel, Tokyo, Japan
Year and Date
20111129-1202
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[Presentation] Hepatoprotective effect and mode of action of acylated phenylethanoid oligoglycosides from Cistanche tubulosa2011
Author(s)
Morikawa T., Ninomiya K., Pan Y., Imura K., Matsuda H., Yoshikawa M., Yuan D., Li Z., Muraoka O.
Organizer
2011 International Conference in Food Factors(ICoFF2011)
Place of Presentation
Taipei International Convention Center, Taipei, Taiwan
Year and Date
20111120-23
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[Presentation] Anti-inflammatory effects of methylated flavonoids from the rhizomes of Kaempferia parviflora2011
Author(s)
Chaipech S., Morikawa T., Matsuda H., Sugawara K., Mukai H., Kiso Y., Ninomiya K., Pongpiriyadacha Y., Hayakawa T., Muraoka O., Yoshikawa M.
Organizer
2011 International Conference in Food Factors(ICoFF2011)
Place of Presentation
Taipei International Convention Center, Taipei, Taiwan
Year and Date
20111120-23
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[Presentation] タイ天然薬物Mammea siamensis花部の機能性成分(1)-新規プレニルクマリンmammeasin類の化学構造とNO産生抑制活性-2011
Author(s)
森川敏生, 末吉真弓, Chaipech Saowanee, 二宮清文, 早川堯夫, 村岡修, 松田久司, 野村友起子, 家邊美久子, 松本明子, 吉川雅之, Pongpiriyadacha Yutana
Organizer
日本生薬学会第58回年会
Place of Presentation
昭和大学旗の台キャンパス,東京
Year and Date
20110924-25
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[Presentation] タイ天然薬物Mammea siamensis花部の機能性成分(2)-新規プレニルクマリンmammeasin類の化学構造とHL-60由来好中球様細胞の活性化抑制作用-2011
Author(s)
森川敏生, 末吉真弓, Chaipech Saowanee, 松田久司, 梅山美樹子, 榊原理恵, 疋田武士, 二宮清文, 吉川雅之, 向井秀仁, 木曽良明, Pongpiriyadacha Yutana, 早川堯夫, 村岡修
Organizer
第61回日本薬学会近畿支部総会・大会
Place of Presentation
神戸学院大学ポートアイランドキャンパス,神戸
Year and Date
2011-10-22
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[Presentation] タイ天然薬物Kaempferia parviflora由来フラボノイド成分のHL-60由来好中球様細胞の活性化抑制作用2010
Author(s)
Chaipech S., 松田久司, 森川敏生, 菅原かおる, 梅山美樹子, 向井秀仁, 木曽良明, 村岡修, 早川堯夫, Pongpiriyadacha Yutana, 吉川雅之
Organizer
第27回和漢医薬学会大会
Place of Presentation
京都薬科大学,京都
Year and Date
20100828-29
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[Presentation] Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa2010
Author(s)
Ninomiya K., Morikawa T., Pan Y., Imura K., Matsuda H., Yoshikawa M., Yuan D., Hayakawa T., Muraoka O.
Organizer
The 5th JSP-CCTNM-KSP Joint Symposium on Pharmacognosy in Tokushima
Place of Presentation
Tokushima Bunri University, Tokushima, Japan
Year and Date
2010-09-24
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