2011 Fiscal Year Final Research Report
Optimization of chemotherapy for breast cancer by in vivo single molecular imaging of drug delivery system and control of neovasculature permeability
| Project/Area Number |
22790031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
KAWAI Masaaki 東北大学, 大学院・医学系研究科, 助教 (80513530)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 虚血性腫瘍 / Quantum Dot / in vivoイメージング |
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| Research Abstract |
To image the neovasculature in the ischemic portion, VEGF-aQDs complexes and mouse ischemic limb model were structured. Injected VEGF-aQDs were attached to the wall of the neovasculature about 3. 3 times higher compared to the aQDs (control). Injected VEGF-aQDs were also attached to the wall of the neovasculature about 2. 4 times higher compared to the wall of the normal vessel. We analyzed the distribution of VEGF receptor on the wall of the neovasculature.
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