2012 Fiscal Year Final Research Report
Design and evaluation of folate-appended cyclodextrin as atumor-selective drug carrier
| Project/Area Number |
22790040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
MOTOYAMA Keiichi 熊本大学, 大学院・生命科学研究部, 准教授 (50515608)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ドラッグデリバリー |
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| Research Abstract |
In the present study, to make an attempt to confer a tumor cell-selectivity to M- -CyD, we newlysynthesized folate-appended M- -CyD (FA-M- -CyD), and evaluated the potentials as its noveltumor-selective carrier for antitumor drugs. Doxorubicin/FA-M- -CyD complex showed the potentantitumor activity after single intravenous injection to tumor-bearing mice, compared to doxorubicinalone and DOX/M- -CyD complex. In conclusion, the present study demonstrated the potentials ofFA-M- -CyD as a novel tumor-selective carrier for antitumor drugs.
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