2011 Fiscal Year Final Research Report
Rational molecular design and synthesis of near-infrared fluorescent probes for in vivo imaging of tumor hypoxia
| Project/Area Number |
22790042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
OKUDA Kensuke 岐阜薬科大学, 薬学部, 講師 (00311796)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / 分析科学 / 低酸素 / インビボ / イメージング / 近赤外蛍光 / 高感度 / 非侵襲性 |
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| Research Abstract |
To visualize the hypoxic status of various tumor cells which are considered to be closely related to malignancy, I developed a probe that emit near-infrared fluorescence, which is suitable for non-invasive bioimaging, under hypoxia. First, to utilize hypoxia selective reductive metabolic reaction, I designed and synthesized probe molecules rationally in the aid of calculation based on density functional theory. Then, I evaluated them using culture cells by fluorescent microscopy. As a result, I invented a molecule that emit near-infrared fluorescence in tumor cells under hypoxic condition specifically.
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