2012 Fiscal Year Final Research Report
Preparation and evaluation of novel oral albumin formulation
| Project/Area Number |
22790044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IWAO Yasunori 静岡県立大学, 薬学部, 助教 (30433022)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 製剤学 |
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| Research Abstract |
In this study, we aimed to develop a novel oral album in formulation with high permeability to the intestinal membrane by using a combination of site-directed mutagenesis and emulsion method. It was found that domain III mutants showed high permeability from the MDCK cells compared with other mutants. In addition, as for the nanoparticles prepared by using the multiple mutated albumins, the nanoparticles showed a good permeability compared with control. These results indicate the feasibility of preparation of recombinant albumin nanoparticles with high permeability to the intestinal membrane.
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[Journal Article] A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.2012
Author(s)
Miyamoto Y, Iwao Y, Mera K, Watanabe H, Kadowaki D, Ishima Y, Giam Chuang VT, Sato K, Otagiri M, Maruyama T.
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Journal Title
Biochemical Pharmacology
Volume: 84
Pages: 1207-1214
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