2011 Fiscal Year Final Research Report
Strategy for therapy of atherosclerotic plaque by drug delivery system using immune-liposomes
| Project/Area Number |
22790046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
CHONO Sumio 北海道薬科大学, 薬学部, 教授 (90347790)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ドラッグデリバリーシステム(DDS) / イムノリポソーム / 動脈プラーク / マクロファージ及び泡沫細胞 |
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| Research Abstract |
Liposomes modified with anti-LOX1antibody(LOX1-liposomes) which recognizes macrophages and foam cells in atherosclerotic plaque were prepared and their efficacy for atherosclerotic therapy was examined. Targeting efficiency of LOX1-liposomes to atherosclerotic plaque of mice was greater than that of non-modified liposomes. Also, LOX1-liposomes containing anti-atherosclerotic drug significantly reduced atherosclerotic plaque of mice. This study suggests that LOX1-liposomes may be a new strategy for therapy of atherosclerotic plaque.
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