2011 Fiscal Year Final Research Report
DEVELOPMENT OF PERSONALIZED ANTICANCER THERAPY BY INHALABLE DRY POWDER BASED ON NONINVASIVE LUNG DEPOSITION MONITORING
| Project/Area Number |
22790051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
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| Research Collaborator |
OKAMOTO Hirokazu 名城大学, 薬学部, 教授 (00308941)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 粉末吸入製剤 / 近赤外蛍光ラベル / in vivoイメージング / 肺癌治療 / 肺内送達 / テーラーメイド医療 / 噴霧急速凍結乾燥法 / 多孔性微粒子 |
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| Research Abstract |
In this study, a novel inhalable dry anticancer powder containing doxorubicin(DOX) was prepared, labeled with a near-infrared fluorescent probe(indocyanin green ; ICG) for easily and noninvasively evaluating lung deposition. Following pulmonary administration of the powder into mice, it was suggested that the in-vivo fluorescence intensity in the lungs derived from ICG was significantly correlated not only with the ex-vivo fluorescence intensity in the excised lungs derived from DOX, but also with the anticancer effect in the lungs.
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Research Products
(4 results)
