2011 Fiscal Year Final Research Report
Bile salt resistance of cell membrane acquired by ABCB4 and PEMT
| Project/Area Number |
22790053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Shiga University of Medical Science (2011)
Kobe Pharmaceutical University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生物物理化学 |
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| Research Abstract |
Phosphatidylethanolamine(PE) is converted to phosphatidylcholine(PC) in the liver by PE N-methyltransferase(PEMT). The expression of PEMT resulted in increased resistance to conjugated bile salts. PEMT may be important in the protection of hepatocytes from bile salts.
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Research Products
(35 results)
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[Journal Article] Essential role of neuron-enriched diacylglycerol kinase(DGK), DGKb in neurite spine formation, contributing to cognitive function2010
Author(s)
Yasuhito Shirai, Takeshi Kouzuki, Kenichi Kakefuda, Shigeki Moriguchi, Atsushi Oyagi, Kyoji Horie, Shin-ya Morita, Masamitsu Shimazawa, Kohji Fukunaga, Junji Takeda, Naoaki Saito, Hideaki Hara
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Journal Title
PLoS ONE
Volume: 5
Pages: 7
Peer Reviewed
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